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SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Inhibition of Polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Reindl, W., Yuan, J., Kramer, A., Strebhardt, K.
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Substrate competitive inhibitors of IGF-1 receptor kinase. Tumor inhibition by genomically integrated inducible RNAi-cassettes. Kappel, S., Matthess, Y., Zimmer, B., Kaufmann, M.
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Effect of RNA silencing of polo-like kinase 1 (PLK1) on apoptosis and spindle formation in human cancer cells. Spankuch-Schmitt, B., Bereiter-Hahn, J., Kaufmann, M. Targeting polo-like kinase 1 for cancer therapy. Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors. Cdk1 is sufficient to drive the mammalian cell cycle. Targeting cell cycle kinases for cancer therapy. Cancer revoked: oncogenes as therapeutic targets. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells. Cancer genes and the pathways they control. Approaches to improving the chemotherapy of Hodgkin's disease. Selected considerations regarding chemotherapy as adjuvant in cancer treatment. A comparative study of two regimens of combination chemotherapy in acute leukemia. Chemotherapeutic studies on trypanosomes. The chemistry and biochemistry of purine analogs. Temporary remissions in acute leukemia in children produced by folic antagonist, 4-aminopteroylglutamic acid (aminopterin). Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Clinical experience with mitomycin C (NSC-26980). Inter-strand crosslinking of DNA by nitrogen mustard. Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Molecular structure of nucleic acids a structure for deoxyribose nucleic acid.
#Magic bullet edius 6 trial#
The initial clinical trial of nitrogen mustard. Nitrogen mustards in the treatment of neoplastic disease. The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. The morphology and motility of Proteus vulgaris and other organisms cultured in the presence of penicillin. Deutsche medizinische Wochenschrift 1893–1896 (1910) (in German).įleming, A., Voureka, A., Kramer, I. Die Behandlung der Syphilis mit dem Ehrlichschen Präparat 606. Berliner klinische Wochenschrift 44, 233–236 (1907) (in German).Įhrlich, P. Chemotherapeutische Trypanosomen-Studien. Berliner klinische Wochenschrift 557–558 (1905) (in German).Įhrlich, P. Ueber den Mechanismus der Antiamboceptorwirkung. Berliner klinische Wochenschrift 37, 453–458 (1900) (in German).Įhrlich, P. Partial cell functions: Nobel lecture, Decemin Physiology or Medicine: including presentation speeches and laureates' biographies 1901–1921 (Elsevier Publishing, Amsterdam, 1967).Įhrlich, P. Handbuch der pathogenen Mikroorganismen 1, 430–451 (1904) (in German).Įhrlich, P. Wirkung und Entstehung der aktiven Stoffe im Serum nach der Seiten-kettentheorie. Ludwig-Maximilians-Universität zu München üblichen Methoden zusammengestellt, 3 Aufl. Anleitung zu hygienischen Untersuchungen: nach den im Hygienischen Institut der königl. Croonian lecture: on immunity with special reference to cell life. Die Wertbemessung des Diphterie-heilserums und deren theoretische Grundlagen. 3rd edn (Minerva, Frankfurt am Main, 1997) (in German).Įhrlich, P. Aus Theorie und Praxis der Chemotherapie. Beiträge zur Theorie und Praxis der histologischen Färbung.